Table 2 Association between GPSleptin and BMI/obese and Overweight according to baseline sleep durationa

From: Childhood sleep duration modifies the polygenic risk for obesity in youth through leptin pathway: the Beijing Child and Adolescent Metabolic Syndrome cohort study

 

Variables

Sleep time ≤ 7 h/day (n = 518)

Sleep time = 8 h/day (n = 1079)

Sleep time = 9 h/day (n = 977)

Sleep hour ≥ 10 h/day (n = 637)

  

β/OR (95% CI)

P

β/OR (95% CI)

P

β/OR (95% CI)

P

β/OR (95% CI)

P

Baseline

BMI (kg.m2)

 

Model 1

0.736 (0.4721.000)

7.2E−8

0.346 (0.162–0.529)

2.3E−4

0.291 (0.1090.474)

0.002

0.245 (0.0250.464)

0.029

 

Model 2

0.723 (0.4441.001)

5.2E−7

0.326 (0.139–0.513)

6.5E−4

0.276 (0.0940.457)

0.003

0.219 (0.0040.442)

0.055

 

Obese and overweight/lean

 

Model 1

1.313 (1.161–1.484)

1.4E−05

1.209 (1.1111.317)

1.2E−5

1.169 (1.0701.277)

0.001

1.092 (0.9851.212)

0.096

 

Model 2

1.328 (1.164–1.516)

2.6E−05

1.213 (1.1091.325)

2.2E−5

1.175 (1.0751.294)

6.0E-4

1.088 (0.9751.214)

0.131

    

Sleep time < median (9 h /day) (n = 312)

 

Sleep time ≥ median (9 h/day) (n = 536)

   
    

β/OR (95% CI)

P

β/OR (95% CI)

P

  

Follow-up

BMI (kg.m−2)

        
 

Model 1

  

0.473 (0.0750.871)

0.020

0.190 (−0.124–0.503)

0.235

  
 

Model 2

  

0.458 (0.0660.849)

0.022

0.190 (−0.124–0.503)

0.235

  
 

Obese and overweight/lean

        
 

Model 1

  

1.324 (1.1201.564)

0.001

1.108 (0.990–1.239)

0.073

  
 

Model 2

  

1.300 (1.0931.546)

0.003

1.106 (0.984–1.2440

0.092

  
  1. Model 1 adjusted for age and sex; model 2 further adjusted for residence, puberty, exercise, and diet score based on model 1
  2. The mean sleep hour was 8.5 h/day
  3. Values in bold are significant at P < 0.004 after Bonferroni correction
  4. GPS genetic predisposition scores
  5. aAll values are expressed as β/OR (95% CI). β/OR (95% CI) and P value for linear and logistic regression in the additive model