Table 3 Direct and indirect effects of GPSleptin on baseline and 10-year follow-up BMI at different values of the sleep duration at baselinea

From: Childhood sleep duration modifies the polygenic risk for obesity in youth through leptin pathway: the Beijing Child and Adolescent Metabolic Syndrome cohort study

Baseline BMI

Follow-up BMI

Conditional direct effects of GPS leptin on baseline and 10-year follow-up BMI at values of the sleep duration:

Sleep duration

Effect

SE

95% CI

P

Sleep duration

Effect

SE

95%CI

P

−1 SD (1.0 h)

0.224

0.050

0.126−0.322

7.5E−6

1 SD (1.0 h)

0.040

0.142

0.319–0.239

0.778

Mean (8.5 h)

0.153

0.036

0.083−0.223

1.8E−5

Mean (8.5 h)

0.082

0.101

0.1160.280

0.416

+1 SD (1.0 h)

0.082

0.050

−0.0162–0.180

0.102

+1 SD (1.0 h)

0.204

0.143

0.0770.485

0.154

Conditional indirect effects of GPS leptin on baseline and 10-year follow-up BMI at values of the sleep duration: through Ln-leptin

Sleep duration

Effect

SE

95% CI

 

Sleep duration

Effect

SE

95%CI

 

−1 SD (1.0 h)

0.302

0.049

0.203−0.395

<0.05

−1 SD (1.0 h)

0.348

0.096

0.165–0.544

<0.05

Mean (8.5 h)

0.223

0.038

0.148−0.301

<0.05

Mean (8.5 h)

0.199

0.075

0.051–0.348

<0.05

 + 1 SD (1.0 h)

0.143

0.057

0.035−0.257

<0.05

+1 SD (1.0 h)

0.049

0.112

−0.174–0.267

 >0.05

  1. β (95% CI) and P value for linear regression in the mediation models
  2. P value was adjusting for age, sex, residence, pubertal stages, diet score, and activity at baseline
  3. Values for moderators i.e., sleep durations are the mean and ±1 SD from mean
  4. Values in bold are significant at P < 0.05
  5. GPS genetic predisposition scores, BMI body mass index
  6. aThe data table shows coefficient estimates for direct and indirect effects of GPSleptin on baseline and 10-year follow-up BMI at values of sleep duration at baseline