Fig. 5: Regulation of lipolysis in adipocytes (after KEGG [25] map 04923).
From: Reduced lipolysis in lipoma phenocopies lipid accumulation in obesity
Lipolysis is stimulated by receptors coupled to stimulative regulative G protein (Gs, upper panel) and inhibited by receptors coupled to inhibitory regulative G protein (Gi, lower panel), which increase or decrease intracellular cAMP level, respectively. Of 27 gene clusters depicted in the pathway, 6 show differential gene expression (red downregulation, green upregulation in lipoma vs. SAT (subcutaneous adipose tissue)). The probability that this is a random event is 0.002. Genes that show differential expression influence the cAMP-signaling pathway and lead to a reduction in cAMP levels in the adipocyte.
