Fig. 4: Top IPA pathways deregulated in the testes in HF diet versus NC conditions.
From: High fat diet causes distinct aberrations in the testicular proteome
a Top Ingenuity pathways associated with altered proteins in the testes from mice fed a HF diet as compared to NC mice. Bars indicate the likelihood [−log (P-value)] that the specific pathway is affected by dietary fat. Protein IDs generated after LC-MS/MS analysis of the global testicular proteome in HF and NC fed mice were put through IPA to generate a total number of curated proteins relevant to that pathway identified in the whole testis. The p value represents the pathway significance to the tissue. Testis specific pathways related to Germ cell-Sertoli cell junction signalling; Germ cell:Germ cell signalling are highlighted in orange. b Top pathway downregulated in testis from HF conditions: caveolar mediated endocytosis signalling, green depicts downregulated proteins in the pathway including FILAMIN A, FILAMIN B, ITGA11 (alpha integrin subunit 11), PTRF/CAV1 (caveolae associated protein).
