Table 2 Associations of PRS-Khera with BMI, obesity, and waist circumference in IDEFICS/I.Family.

From: Polygenic risk for obesity and its interaction with lifestyle and sociodemographic factors in European children and adolescents

(A) BMI

 

BMI

Obesity

Scale of PRS

Est., 95% CI

p value

R²

OR, 95% CI

p value

AUC

Continuous

0.33 [0.30, 0.37]

7.9e − 81

0.108

2.33 [2.01, 2.70]

2.0e − 29

0.736

Top decile

0.61 [0.49, 0.73]

5.4e − 24

0.036

3.63 [2.57, 5.14]

2.7e − 13

0.598

(B) Waist circumference

 

Waist circumference

Waist top quartile

Scale of PRS

Est., 95% CI

p value

R²

OR, 95% CI

p value

AUC

Continuous

0.36 [0.32, 0.40]

1.8e − 71

0.088

1.97 [1.78, 2.17]

1.5e − 40

0.683

Top decile

0.69 [0.55, 0.82]

8.8e − 24

0.032

3.09 [2.37, 4.03]

6.1e − 17

0.569

  1. Associations adjusted for region of residence, sex, age, parental education, fruit and vegetable score. Z scores for BMI and waist circumference were calculated according to refs. [27, 28]. Obesity was defined according to the extended IOTF criteria [27].
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