Fig. 5: TCTP overexpression improves systemic metabolic homeostasis in mice with HFD-induced obesity. | International Journal of Obesity

Fig. 5: TCTP overexpression improves systemic metabolic homeostasis in mice with HFD-induced obesity.

From: Overexpression of translationally controlled tumor protein ameliorates metabolic imbalance and increases energy expenditure in mice

Fig. 5

A Changes in body weight and B Final body weight of WT and TCTP TG (\(n = 10\)). C Daily food intake and D food efficiency rate (FER) of WT and TCTP TG (\(n = 10\)). E Fat mass and F lean mass of 10-week-old WT and TCTP TG (\(n = 6\)). Masses were measured by LF50 (BRUKER, Germany) and normalized to the body weight. G Normalized weights of the liver, EpiWAT, IngWAT, IBAT and muscle (\(n = 6\)). H H&E staining of EpiWAT and histomorphometric analyses of adipocyte area, and I size distribution of EpiWAT (\(n = 6 - 7\)). The images were magnified by 10X and scale bar is 100 μm. J FFA level and K cholesterol in plasma of WT and TCTP TG (\(n = 5 - 7\)). L H&E staining of the liver. (\(n = 5 - 6\)). M Triglyceride and N cholesterol of the liver, and O plasma ALT level. P Blood glucose levels after overnight fast (\(n = 6\)). Q IP-GTT and quantification of the area AUC (\(n = 5\)). Two-way ANOVA: time effect, P < 0.0001. Interaction, P < 0.05. Unpaired t-test; *P < 0.05, **P < 0.01, ***P < 0.001. R IP-ITT and quantification of AUC (\(n = 5\)). Two-way ANOVA: time effect, P < 0.0001. Unpaired t-test; *P < 0.05, **P < 0.01. The images were magnified by 10X and scale bar is 100 μm. Data are mean ± SEM. Unpaired t-test; *P < 0.05, **P < 0.01, ***P < 0.001.

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