Fig. 4: BAT attenuates expression of genes involved in inflammation and insulin resistance increased by MI in white adipose tissue and liver. | International Journal of Obesity

Fig. 4: BAT attenuates expression of genes involved in inflammation and insulin resistance increased by MI in white adipose tissue and liver.

From: Brown adipose tissue prevents glucose intolerance and cardiac remodeling in high-fat-fed mice after a mild myocardial infarction

Fig. 4

Quantitative PCR (qPCR) was performed on tissue isolated from mice that were sacrificed at 52 weeks of age (22 weeks post-MI). Genes related to inflammation and fibrosis, insulin signaling and glucose metabolism, fatty acid metabolism, and mitochondrial biogenesis were accessed in (A–C) pgWAT, (D–F) scWAT, and (G–I) liver of Sham (n = 8), Sham-MI (n = 3–5), +BAT (n = 5–8), and +BAT-MI (n = 4–5). Data are presented as mean + S.E.M (n = 5–9/group). Two-way ANOVA was used with Tukey’s multiple comparisons tests. *symbols represent the difference of Sham-MI or +BAT vs. Sham mice (*p < 0.05). # symbols represent difference of Sham-MI versus +BAT-MI mice (#p < 0.05).

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