Table 1 Study population characteristics.

From: Pituitary T1 signal intensity at magnetic resonance imaging is reduced in patients with obesity: results from the CHIASM study

	Obese cohort (BMI ≥ 30 kg/m²)	Non-obese cohort (BMI < 30 kg/m²)	p
N	69	25
Age (years)	45.28 ± 12.33	43.36 ± 14.68	0.529
Sex			0.935
Men, n/total (%)	16/69 (23.19%)	6/25 (24.00%)
Women, n/total (%)	53/69 (76.81%)	19/25 (76.00%)
Anthropometric parameters
Weight	106.1 ± 22.86	75.26 ± 7.54	<0.001
BMI	38.76 ± 6.41	26.00 ± 3.26	<0.001
Waist circumference	118.4 ± 14.41	96.91 ± 11.09	<0.001
Hip circumference	122.9 ± 12.54	103.9 ± 3.44	<0.001
Pituitary MRI
Pituitary volume (mm³)	403.2 ± 159.7	404.2 ± 157.6	0.979
Total empty sella, n/total (%)	4/69 (5.79%)	0/25 (0%)	0.212
DEXA evaluation
Total fat, %	38.02 ± 6.67	30.72 ± 7.79	<0.001
Total fat, kg	39.50 ± 11.85	22.45 ± 6.94	<0.001
Lean mass, %	60.95 ± 7.17	68.62 ± 7.47	<0.001
Lean mass, kg	60.98 ± 11.96	48.47 ± 8.11	<0.001
Truncal fat, %	36.98 ± 6.42	27.66 ± 8.36	<0.001
Truncal fat, g	18.81 ± 7.05	9.81 ± 3.96	<0.001
Biochemical assessment
Glucose	101.2 ± 31.78	90.59 ± 9.46	0.105
Insulin	21.71 ± 20.17	9.49 ± 10.66	0.028
HOMA-index	5.61 ± 6.23	2.16 ± 2.59	0.001
HbA1c	6.23 ± 4.34	5.16 ± 0.46	0.240
Urate	5.38 ± 1.33	4.66 ± 0.94	0.018
White blood cells	7.65 ± 1.99	6.37 ± 1.77	0.006
Neutrophils	4.25 ± 1.52	3.13 ± 1.47	0.020
Lymphocytes	2.23 ± 0.89	1.72 ± 0.71	0.005
Neutrophil-to-lymphocyte ratio	2.05 ± 0.80	1.86 ± 0.56	0.281
ESR	25.17 ± 18.17	15.63 ± 9.91	0.030
C-reactive protein	1.07 ± 2.25	0.36 ± 0.37	0.140
Fibrinogen	352.6 ± 109.4	285.7 ± 80.90	0.009
Hormone evaluation
TSH	2.02 ± 1.45	2.23 ± 1.76	0.550
FT3	3.27 ± 0.85	3.01 ± 0.70	0.169
FT4	1.23 ± 0.35	1.45 ± 1.81	0.554
PRL	22.21 ± 42.95	22.22 ± 42.95	0.447
GH	0.94 ± 1.63	1.71 ± 2.61	0.201
IGF-1 (ng/L)	158.6 ± 70.7	155.5 ± 78.72	0.894
ACTH (pg/mL)	34.38 ± 16.60	40.73 ± 24.54	0.322
Cortisol (nmol/L)	364.7 ± 126.1	364.3 ± 162.5	0.730
Testosterone (men) (ng/dL)	4.00 ± 1.88	4.45 ± 2.33	0.655
Vitamin D < 30 ng/mL or replacement	52/69 (75.36%)	17/25 (68.00%)	0.710

Variables showing a statistically significant difference between the cohorts are shown in bold.

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Table 1 Study population characteristics.

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