Table 2 Difference in pituitary MRI volume and signal intensity changes between the subgroup who achieved weight loss and the subgroup with stable or increased weight at follow-up.

From: Pituitary T1 signal intensity at magnetic resonance imaging is reduced in patients with obesity: results from the CHIASM study

 

Subgroup with stable weight loss (decrease from baseline > 5%)

Subgroup with stable or increased weight

p

N

17

16

 

Volume change

−0.40 (−41.6 to 40.7) mm3

−63.3 (−108.8 to −17.9) mm3

0.047*

BMI change

−6.64 ± 5.68 kg/m2

2.02 ± 2.17 kg/m2

<0.001

Truncal fat change

−4.20 ± 6.38

3.05 ± 4.11

0.003

T1-weighted signal change

−0.17 (−4.26 to 3.92) %

−6.60 (−10.69 to −2.50) %

0.012**

T1-weighted post-enhanced signal change

2.25 (−4.58 to 9.07) %

−11.49 (−19.25 to −3.73) %

0.017**

  1. Variables showing a statistically significant difference between the cohorts are shown in bold.
  2. *Values are expressed as estimated means (lower-upper limit of 95% confidence interval [CI]). Covariates in the model: age and baseline volume.
  3. **Values are expressed as estimated means (lower-upper limit of 95% CI). Covariates in the model: age, baseline, and 3-year follow-up white matter signal intensity.
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