Table 2 Odds of incident diabetes at 5 years by measured and predicted values for intrahepatic fat and visceral fata.

From: Adipose tissue-derived metabolite risk scores and risk for type 2 diabetes in South Asians

 

Oddsb of Incident Diabetes, Odds Ratio [95% CI]

 

Unadjusted

P value

Model 1c

P value

Model 2d

P value

 

Hepatic fat, measured by CT or metabolite score

Intrahepatic fata

1.61 [1.23, 2.10]

4.48e−04

1.65 [1.25, 2.16]

3.26e−04

1.53 [1.13, 2.10]

6.71e−03

MET-Liver

1.91 [1.38, 2.65]

1.1e−04

2.04 [1.46, 2.86]

3.33e−05

2.04 [1.37, 3.03]

3.91e−04

 

Visceral fat, measured by CT or metabolite score

Visceral fat

1.76 [1.36, 2.27]

1.76e−05

1.86 [1.39, 2.48]

2.44e−05

1.98 [1.26, 3.11]

3.18e−03

MET-Visc

2.23 [1.52, 3.25]

3.46e−05

2.43 [1.67, 3.55]

4.25e−06

2.80 [1.75, 4.46]

1.53e−05

 

Metabolite-derived adiposity scores adjusted for CT-measured adiposity

MET-Liver, adjusted for Intrahepatic fat

–

–

–

–

1.87 [1.06, 3.27]

0.03

MET-Visc, adjusted for visceral fat

–

–

–

–

2.38 [1.34, 4.25]

3.20e−03

 

Measured visceral fat area adjusted for hepatic attenuation

Intrahepatic fat

–

–

–

–

1.36 [0.97, 1.92]

0.08

Visceral fat

–

–

–

–

1.78 [1.08, 2.93]

0.02

  1. aInverse hepatic attenuation in Hounsfield units (HU*-1) visceral fat area (cm2).
  2. bOR by z-score of inverse hepatic attenuation or visceral fat area (cm2).
  3. cAdjusted for age, gender, study site.
  4. dModel 1 + adjustment for BMI (kg/m2), energy intake (kCal/day), Alternative Health Eating Index-2010 (AHEI-2010), physical activity (MET-minutes/week), use of lipid-lowering medications.
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