Fig. 6: One week on HFD induces upregulation of FGF23 and mild gastric lesions harboring FGF23+ cells, CD45+ immune cells and lipid accumulation.
From: High fat diet induces gastric production of fibroblast growth factor 23 (FGF23)
Arithmetic means ± SEM of relative gastric transcript levels of Fgf23 (A), Sox2 (B), Il-6 (C), and Il-11 (D) normalized to Rpl8 after one week on HFD compared to CD-fed mice (CD: n = 5; HFD: n = 4; student’s t-test). Contiguous sections showing the formation of narrow-lumened FGF23+ interconnected blood vessels (E) surrounded by CD45+ cells (F). FGF23+ blood vessel (G) containing Nile red-stained lipid deposits (H) of contiguous sections. (CD: n = 5; HFD: n = 4). Sections were counterstained with DAPI. Scale bars (E–H): 50 μm. *p < 0.05; **p < 0.01. bp base pairs, CD control diet, CD45 cluster of differentiation 45, Fgf23 fibroblast growth factor 23, HFD high fat diet, Il-6 interleukin 6, Il-11 interleukin 11, Rpl8 ribosomal protein L8, Sox2 SRY-box transcription factor 2.
