Table 3 Entero-pancreatic dynamics following a mixed meal.
C-RYGB | M-RYGB | SADI-S | BPD-DS | |
|---|---|---|---|---|
Glucose | ||||
Fasted (mmol/L) | 4.5 [4.2–4.8] | 4.6 [4.3–4.8] | 4.4 [4.0–4.7] | 4.4 [4.1–4.7] |
Peak (mmol/L) | 8.8 (8.5–9.4) | 8.8 (7.2–9.2) | 7.0 (6.6–8.2) | 5.4 (5.2–6.7) |
Nadir (mmol/L) | 2.8 [2.3–3.4] | 3.4 [2.9–3.8] | 3.7 [3.1–4.2] | 3.0 [2.5–3.6] |
MMGR | 3.3 [2.6–3.9] | 2.5 [2.1–3.0] | 2.0 [1.8–2.2] | 2.0 [1.6–2.3] |
tAUC (0’–30’) (mmol/L × min) | 208 [194–222] | 190 [177–204] | 168 [157–180] | 149 [136–162] |
tAUC (0’–120’) (mmol/L × min) | 637 [587–687] | 683 [596–770] | 620 [536–705] | 526 [441–611] |
TAA | ||||
Fasted (μmol/L) | 1627 [1389–1864] | 1336 [994–1678] | 1161 [867–1455] | 1042 [884–1201] |
tAUC (0’–45’) (mmol/L × min) | 114.2 [101.2–127.2] | 99.0 [75.7–122.3] | 93.4 [72.0–114.4] | 59.2 [43.4–75.0] |
tAUC (0’–120’) (mmol/L × min) | 268.4 (261.5–294.8) | 262.8 (234.9–295.4) | 245.4 (231.9–269.6) | 123.6 (105.5–204.5) |
Heart rate | ||||
Fasted (bpm) | 62 (55–71) | 60 (58–76) | 64 (57–73) | 67 (55–80) |
tAUC (0’–30’) (bpm × min) | 2436 (2247–2715) | 2119 (2006–2490) | 2051 (1721–2085) | 2040 (1767–2399) |
tAUC (0’–120’)(bpm × min) | 9306 (8795–10204) | 8486 (7886–10035) | 8419 (7785–9053) | 8250 (7616–9419) |
Insulin | ||||
Fasted (pmol/L) | 45.7 (41.9–54.5) | 33.8 (26.7–47.3) | 30.8 (19.0–40.4) | 35.2 (21.0–45.3) |
tAUC (0’–45’) (nmol/L × min) | 64.6 (34.7–78.7) | 26.2 (12.3–29.3) | 22.5 (15.8–35.4) | 17.3 (10.8–29.2) |
tAUC (0’–120’) (nmol/L × min) | 94.8 [65.2–124.3] | 54.3 [37.9–70.7] | 44.7 [31.7–57.8] | 37.5 [25.5–49.5] |
C-peptide | ||||
Fasted (pmol/L) | 578.1 (499.1–615.8) | 478.3 (373.9–580.6) | 399.0 (333.8–532.1) | 330.3 (309.3–495.9) |
tAUC (0’–45’) (nmol/L × min) | 154.3 (99.5–172.3) | 84.9 (61.2–91.1) | 66.5 (60.1–90.4) | 59.9 (44.4–70.8) |
tAUC (0’–120’) (nmol/L × min) | 322.6 (241.2–380.5) | 227.5 (186.3–297.6) | 176.9 (160.8–242.2) | 167.0 (145.4–194.3) |
Glucagon | ||||
tAUC (0’–30’) (nmol/L × min) | 322.7 [257.3–388.2] | 343.9 [198.8–489.1] | 414.9 [285.4–544.4] | 332.9 [271.8–393.9] |
tAUC (0’–120’) (nmol/L × min) | 1428 [1144–1713] | 1746 [1193–2298] | 1650 [1194–2106] | 1285 [901.6–1668] |
Total GIP | ||||
tAUC (0’–30’) (pmol/L × min) | 1632 (1536–2340) | 922 (742–1103) | 540 (257–938) | 390 (236–841) |
tAUC (0’–120’) (pmol/L × min) | 5018 (4281–6925) | 3420 (2498–3668) | 1628 (864–4389) | 1418 (1181–3389) |
Total GLP-1 | ||||
tAUC (0’–30’) (pmol/L × min) | 2869 (2239–3358) | 2633 (2048–2970) | 1828 (1562–3048) | 1527 (1267–2676) |
tAUC (0’–120’) (pmol/L x min) | 7898 (6205–10142) | 13388 (7808–14670) | 6612 (5948–9485) | 5993 (4576–9117) |
Neurotensin | ||||
tAUC (0’–30’) (pmol/L × min) | 3004 (2014–5546) | 3900 (2018–5153) | 2012 (1159–4013) | 2455 (2150–3181) |
tAUC (0’–120’) (pmol/L × min) | 12481 (7707–16622) | 17025 (10553–21638) | 9360 (6176–15630) | 14010 (12110–15488) |
