Table 1 140 Metabolite markers and 2 ratios correlated with BMI classifications (FDR < 0.05).
Marker | Group | Coefficient | p value | FDR |
|---|---|---|---|---|
Gly | Amino acids | −0.3111 | 3.73E−09 | 9.77E−07 |
Tyr | Amino acids | 0.279 | 1.62E−07 | 3.12E−05 |
Val | Amino acids | 0.2377 | 5.21E−06 | 6.95E−04 |
Total_BCAA | Amino acids | 0.2131 | 4.98E−05 | 5.78E−03 |
His | Amino acids | −0.2149 | 9.00E−05 | 9.80E−03 |
ApoB | Apolipoproteins | 0.2972 | 3.03E−08 | 6.65E−06 |
ApoA1 | Apolipoproteins | −0.261 | 2.29E−07 | 4.29E−05 |
HDL_C | Cholesterol | −0.3424 | 1.17E−11 | 4.76E−09 |
VLDL_C | Cholesterol | 0.3521 | 7.49E−11 | 2.55E−08 |
Remnant_C | Cholesterol | 0.2638 | 9.07E−07 | 1.41E−04 |
non_HDL_C | Cholesterol | 0.2382 | 6.56E−06 | 8.56E−04 |
LDL_C | Cholesterol | 0.2088 | 6.15E−05 | 6.96E−03 |
Clinical_LDL_C | Cholesterol | 0.2086 | 6.82E−05 | 7.60E−03 |
HDL_CE | Cholesteryl esters | −0.3566 | 1.74E−12 | 8.58E−10 |
VLDL_CE | Cholesteryl esters | 0.3345 | 6.53E−10 | 1.94E−07 |
LDL_CE | Cholesteryl esters | 0.2188 | 2.57E−05 | 3.07E−03 |
MUFA_pct | Fatty acids | 0.3163 | 5.00E−09 | 1.23E−06 |
PUFA_by_MUFA | Fatty acids | −0.285 | 5.60E−08 | 1.14E−05 |
Omega_6_pct | Fatty acids | −0.2298 | 6.60E−06 | 8.56E−04 |
MUFA | Fatty acids | 0.2359 | 7.20E−06 | 9.25E−04 |
PUFA_pct | Fatty acids | −0.2028 | 5.38E−05 | 6.14E−03 |
VLDL_FC | Free cholesterol | 0.375 | 3.87E−12 | 1.72E−09 |
HDL_FC | Free cholesterol | −0.2851 | 1.66E−08 | 3.81E−06 |
GlycA | Inflammation | 0.3724 | 1.11E−12 | 5.64E−10 |
VLDL_P | Lipoprotein particle concentrations | 0.3623 | 2.69E−11 | 1.01E−08 |
LDL_P | Lipoprotein particle concentrations | 0.2946 | 3.68E−08 | 7.72E−06 |
HDL_P | Lipoprotein particle concentrations | −0.1772 | 4.10E−04 | 0.0412 |
HDL_size | Lipoprotein particle sizes | −0.5136 | 1.34E−22 | 6.37E−19 |
VLDL_size | Lipoprotein particle sizes | 0.4156 | 2.00E−15 | 1.90E−12 |
L_HDL_CE | Lipoprotein subclasses | −0.5624 | 3.36E−24 | 4.80E−20 |
L_HDL_C | Lipoprotein subclasses | −0.5517 | 4.95E−23 | 3.53E−19 |
L_HDL_P | Lipoprotein subclasses | −0.5034 | 4.18E−21 | 1.49E−17 |
L_HDL_L | Lipoprotein subclasses | −0.4907 | 1.91E−20 | 5.46E−17 |
L_HDL_FC | Lipoprotein subclasses | −0.5336 | 2.56E−18 | 4.79E−15 |
L_HDL_PL | Lipoprotein subclasses | −0.4977 | 2.69E−18 | 4.79E−15 |
L_VLDL_L | Lipoprotein subclasses | 0.4624 | 2.38E−18 | 4.79E−15 |
XL_VLDL_L | Lipoprotein subclasses | 0.4474 | 2.03E−17 | 2.90E−14 |
L_VLDL_TG | Lipoprotein subclasses | 0.5011 | 1.21E−16 | 1.57E−13 |
L_VLDL_FC | Lipoprotein subclasses | 0.4285 | 3.82E−16 | 4.55E−13 |
L_VLDL_P | Lipoprotein subclasses | 0.4281 | 7.64E−16 | 8.39E−13 |
XL_HDL_CE | Lipoprotein subclasses | −0.461 | 8.13E−15 | 7.25E−12 |
XL_VLDL_P | Lipoprotein subclasses | 0.4094 | 1.43E−14 | 1.20E−11 |
L_VLDL_C | Lipoprotein subclasses | 0.4024 | 2.70E−14 | 2.03E−11 |
XL_VLDL_C | Lipoprotein subclasses | 0.4027 | 2.91E−14 | 2.07E−11 |
XL_VLDL_CE | Lipoprotein subclasses | 0.3852 | 2.32E−13 | 1.56E−10 |
M_VLDL_TG | Lipoprotein subclasses | 0.3748 | 6.22E−13 | 3.55E−10 |
XL_HDL_L | Lipoprotein subclasses | −0.3973 | 8.66E−13 | 4.57E−10 |
L_VLDL_CE | Lipoprotein subclasses | 0.373 | 2.15E−12 | 1.02E−09 |
XL_HDL_C | Lipoprotein subclasses | −0.4261 | 3.76E−12 | 1.72E−09 |
S_VLDL_P | Lipoprotein subclasses | 0.3783 | 6.08E−12 | 2.63E−09 |
S_VLDL_L | Lipoprotein subclasses | 0.3749 | 7.24E−12 | 3.04E−09 |
S_VLDL_CE | Lipoprotein subclasses | 0.3691 | 1.40E−11 | 5.54E−09 |
M_VLDL_L | Lipoprotein subclasses | 0.3488 | 4.50E−11 | 1.61E−08 |
XL_VLDL_FC | Lipoprotein subclasses | 0.3437 | 6.75E−11 | 2.35E−08 |
XL_HDL_P | Lipoprotein subclasses | −0.3867 | 8.30E−11 | 2.75E−08 |
S_VLDL_C | Lipoprotein subclasses | 0.3518 | 9.87E−11 | 3.20E−08 |
S_HDL_TG | Lipoprotein subclasses | 0.3428 | 1.75E−10 | 5.53E−08 |
S_VLDL_PL | Lipoprotein subclasses | 0.3403 | 3.34E−10 | 1.04E−07 |
M_VLDL_P | Lipoprotein subclasses | 0.3346 | 4.79E−10 | 1.46E−07 |
M_HDL_CE | Lipoprotein subclasses | −0.3002 | 3.34E−09 | 9.00E−07 |
XL_VLDL_PL | Lipoprotein subclasses | 0.3099 | 4.67E−09 | 1.17E−06 |
M_VLDL_PL | Lipoprotein subclasses | 0.3054 | 7.80E−09 | 1.89E−06 |
S_VLDL_FC | Lipoprotein subclasses | 0.3101 | 9.59E−09 | 2.28E−06 |
M_HDL_C | Lipoprotein subclasses | −0.2883 | 1.23E−08 | 2.87E−06 |
S_LDL_TG | Lipoprotein subclasses | 0.3004 | 2.76E−08 | 6.26E−06 |
XL_VLDL_TG | Lipoprotein subclasses | 0.2664 | 2.91E−08 | 6.48E−06 |
M_VLDL_FC | Lipoprotein subclasses | 0.2973 | 3.15E−08 | 6.82E−06 |
L_LDL_P | Lipoprotein subclasses | 0.2956 | 3.32E−08 | 7.06E−06 |
M_LDL_P | Lipoprotein subclasses | 0.2934 | 3.95E−08 | 8.17E−06 |
S_VLDL_TG | Lipoprotein subclasses | 0.2961 | 6.23E−08 | 1.25E−05 |
M_HDL_P | Lipoprotein subclasses | −0.2697 | 9.12E−08 | 1.78E−05 |
XS_VLDL_FC | Lipoprotein subclasses | 0.2738 | 2.51E−07 | 4.58E−05 |
XS_VLDL_P | Lipoprotein subclasses | 0.2783 | 2.81E−07 | 5.08E−05 |
L_VLDL_PL | Lipoprotein subclasses | 0.2553 | 3.22E−07 | 5.75E−05 |
XS_VLDL_L | Lipoprotein subclasses | 0.2765 | 3.36E−07 | 5.92E−05 |
M_HDL_L | Lipoprotein subclasses | −0.2574 | 3.45E−07 | 5.93E−05 |
XXL_VLDL_CE | Lipoprotein subclasses | 0.2751 | 3.43E−07 | 5.93E−05 |
M_LDL_TG | Lipoprotein subclasses | 0.2711 | 3.53E−07 | 5.99E−05 |
XL_HDL_PL | Lipoprotein subclasses | −0.3125 | 4.70E−07 | 7.70E−05 |
XXL_VLDL_P | Lipoprotein subclasses | 0.2642 | 5.37E−07 | 8.61E−05 |
M_LDL_CE | Lipoprotein subclasses | 0.2584 | 5.89E−07 | 9.24E−05 |
M_HDL_PL | Lipoprotein subclasses | −0.2481 | 9.98E−07 | 1.53E−04 |
L_LDL_TG | Lipoprotein subclasses | 0.2577 | 1.25E−06 | 1.89E−04 |
S_LDL_P | Lipoprotein subclasses | 0.2597 | 1.29E−06 | 1.93E−04 |
S_LDL_L | Lipoprotein subclasses | 0.255 | 1.33E−06 | 1.98E−04 |
M_LDL_L | Lipoprotein subclasses | 0.2503 | 1.41E−06 | 2.07E−04 |
S_LDL_CE | Lipoprotein subclasses | 0.2517 | 1.74E−06 | 2.53E−04 |
S_LDL_PL | Lipoprotein subclasses | 0.2526 | 1.91E−06 | 2.72E−04 |
M_LDL_PL | Lipoprotein subclasses | 0.2469 | 1.94E−06 | 2.74E−04 |
M_LDL_C | Lipoprotein subclasses | 0.2455 | 2.21E−06 | 3.07E−04 |
XXL_VLDL_C | Lipoprotein subclasses | 0.2541 | 2.21E−06 | 3.07E−04 |
XS_VLDL_C | Lipoprotein subclasses | 0.2493 | 3.79E−06 | 5.15E−04 |
S_LDL_C | Lipoprotein subclasses | 0.2409 | 4.54E−06 | 6.10E−04 |
M_VLDL_C | Lipoprotein subclasses | 0.2449 | 6.35E−06 | 8.39E−04 |
IDL_TG | Lipoprotein subclasses | 0.2422 | 7.53E−06 | 9.60E−04 |
M_HDL_FC | Lipoprotein subclasses | −0.218 | 9.76E−06 | 1.22E−03 |
XS_VLDL_TG | Lipoprotein subclasses | 0.2373 | 1.51E−05 | 1.85E−03 |
IDL_P | Lipoprotein subclasses | 0.2318 | 1.54E−05 | 1.88E−03 |
XS_VLDL_CE | Lipoprotein subclasses | 0.2293 | 2.15E−05 | 2.59E−03 |
XS_VLDL_PL | Lipoprotein subclasses | 0.1983 | 4.36E−05 | 5.09E−03 |
XXL_VLDL_L | Lipoprotein subclasses | 0.2129 | 5.03E−05 | 5.79E−03 |
XXL_VLDL_PL | Lipoprotein subclasses | 0.2121 | 6.23E−05 | 6.99E−03 |
M_LDL_FC | Lipoprotein subclasses | 0.2057 | 7.96E−05 | 8.81E−03 |
L_LDL_PL | Lipoprotein subclasses | 0.2057 | 8.57E−05 | 9.41E−03 |
S_LDL_FC | Lipoprotein subclasses | 0.2018 | 1.21E−04 | 0.0129 |
L_LDL_L | Lipoprotein subclasses | 0.1992 | 1.35E−04 | 0.0143 |
L_LDL_CE | Lipoprotein subclasses | 0.1971 | 1.51E−04 | 0.0159 |
L_LDL_C | Lipoprotein subclasses | 0.1884 | 3.04E−04 | 0.0312 |
M_VLDL_CE | Lipoprotein subclasses | 0.2262 | 3.23E−04 | 0.0329 |
IDL_PL | Lipoprotein subclasses | 0.192 | 3.32E−04 | 0.0336 |
TG_by_PG | Other lipids | 0.4456 | 7.98E−18 | 1.26E−14 |
VLDL_PL | Phospholipids | 0.3919 | 4.75E−13 | 2.95E−10 |
HDL_PL | Phospholipids | −0.2977 | 4.35E−09 | 1.11E−06 |
LDL_PL | Phospholipids | 0.2271 | 1.45E−05 | 1.80E−03 |
L_HDL_CE_pct | Relative lipoprotein lipid concentrations | −0.6231 | 2.40E−13 | 1.56E−10 |
L_HDL_C_pct | Relative lipoprotein lipid concentrations | −0.6828 | 8.07E−13 | 4.43E−10 |
XL_HDL_TG_pct | Relative lipoprotein lipid concentrations | 0.3728 | 1.93E−11 | 7.46E−09 |
S_HDL_TG_pct | Relative lipoprotein lipid concentrations | 0.3525 | 3.36E−11 | 1.23E−08 |
XL_HDL_C_pct | Relative lipoprotein lipid concentrations | 0.3478 | 9.63E−10 | 2.80E−07 |
M_HDL_C_pct | Relative lipoprotein lipid concentrations | −0.3295 | 1.01E−09 | 2.88E−07 |
L_LDL_FC_pct | Relative lipoprotein lipid concentrations | −0.3226 | 1.22E−09 | 3.35E−07 |
M_HDL_CE_pct | Relative lipoprotein lipid concentrations | −0.3208 | 3.76E−09 | 9.77E−07 |
M_HDL_PL_pct | Relative lipoprotein lipid concentrations | 0.2745 | 6.86E−08 | 1.36E−05 |
M_LDL_FC_pct | Relative lipoprotein lipid concentrations | −0.2777 | 2.09E−07 | 3.98E−05 |
XL_HDL_FC_pct | Relative lipoprotein lipid concentrations | 0.2369 | 2.42E−07 | 4.48E−05 |
M_LDL_CE_pct | Relative lipoprotein lipid concentrations | 0.2563 | 4.20E−07 | 7.06E−05 |
XL_VLDL_CE_pct | Relative lipoprotein lipid concentrations | −0.2653 | 4.39E−07 | 7.29E−05 |
M_VLDL_CE_pct | Relative lipoprotein lipid concentrations | −0.4099 | 5.47E−07 | 8.66E−05 |
S_HDL_PL_pct | Relative lipoprotein lipid concentrations | −0.261 | 1.78E−06 | 2.56E−04 |
XL_VLDL_C_pct | Relative lipoprotein lipid concentrations | −0.2442 | 3.21E−06 | 4.41E−04 |
M_HDL_TG_pct | Relative lipoprotein lipid concentrations | 0.2289 | 9.18E−06 | 1.16E−03 |
L_HDL_PL_pct | Relative lipoprotein lipid concentrations | 0.6495 | 3.94E−05 | 4.65E−03 |
M_VLDL_C_pct | Relative lipoprotein lipid concentrations | −0.2183 | 9.30E−05 | 0.01 |
L_HDL_TG_pct | Relative lipoprotein lipid concentrations | 0.1946 | 2.72E−04 | 0.0285 |
M_LDL_TG_pct_by_L_HDL_PL | Relative lipoprotein lipid concentrations/Lipoprotein subclasses | −0.0114 | 2.76E−04 | 0.0287 |
XL_VLDL_TG_pct_by_L_HDL_TG | Relative lipoprotein lipid concentrations/Lipoprotein subclasses | 0.0278 | 2.82E−04 | 0.0291 |
VLDL_L | Total lipids | 0.4117 | 2.25E−14 | 1.78E−11 |
HDL_L | Total lipids | −0.3075 | 1.19E−09 | 3.32E−07 |
LDL_L | Total lipids | 0.2195 | 2.58E−05 | 3.07E−03 |
VLDL_TG | Triglycerides | 0.4308 | 1.35E−15 | 1.38E−12 |
Total_TG | Triglycerides | 0.3882 | 6.02E−13 | 3.55E−10 |
LDL_TG | Triglycerides | 0.2679 | 5.00E−07 | 8.11E−05 |