Fig. 5
From: RANKL deletion in periodontal ligament and bone lining cells blocks orthodontic tooth movement
RANKL deletion in PDL and bone lining cells decreases osteoclast numbers in response to orthodontic forces. Osteoclasts were measured as bone lining, multi-nucleated, TRAP+ cells. a Representative images of TRAP stained sections (100x original magnification, distobuccal root). Bar, 100 μm. Cp, compression side; Ts: tension side. Yellow arrows indicate osteoclasts. b and c Quantification of osteoclasts on day 5 and 12. Each value is the mean ± SEM for n=8 mice per group. *P < 0.05 versus Col1α1.CreERTM−.RANKLf/f mice. **P < 0.05 versus no mechanical force in control Col1α1.CreERTM−.RANKLf/f mice. PDL, periodontal ligament; RANKL, nuclear factor-κB ligand; DB, distobuccal root
