Fig. 2
From: TGF-β2 downregulates osteogenesis under inflammatory conditions in dental follicle stem cells
In vivo transplantation of normal and inflamed DFSCs. a H&E staining was performed to determine the amount of hard tissue formed by transplanted normal and inflamed DFSCs with HA/TCP after 8 weeks transplantation to the dorsal skin of nude mice. Inflamed DFSCs showed significantly less hard tissue formation. b Dense collections of human mitochondria were detected in areas of hard tissue formation. c, d Hard tissue regions were positively stained for human osteocalcin and type 1 collagen to confirm hard tissue formation by transplanted normal and inflamed DFSCs. The two groups showed significantly different amounts of bone formation
