Table 3 Concentrations of saliva proteases detected by ELISA

From: Salivary protease spectrum biomarkers of oral cancer

Analyte/control

Healthy

JBO fibroma

OSCC

CPD

(Mean OD)

(Mean OD)

(Mean OD)

(Mean OD)

ADAM8

0

0.101 ± 0.001

0.486 ± 0.110a

0.205 ± 0.03

ADAM9

0

0

0.367 ± 0.05a

0.11 ± 0.002

ADAMTS1

0

0

0.177 ± 0.009a

0.09 ± 0

ADAMTS13

0

0

0.294 ± 0.025c

0

MMP-1

0

0

0.304 ± 0.103

0

MMP-2

0

0

0.878 ± 0.315

0

MMP-3

0

0

0.718 ± 0.209

0

MMP-7

0

0

0.304 ± 0.115a

0.115 ± 0.091

MMP-8

0.835 ± 0.219

1.116 ± 0.306

0.978 ± 0.315

0.965 ± 0.298

MMP-9

1.012 ± 0.303

0.584 ± 0.198

0.156 ± 0.09b

0.538 ± 0.126

MMP-10

0

0

0.969 ± 0.312

0

MMP-12

0

0

0.365 ± 0.113a

0.12 ± 0.08

MMP-13

0

0

0.375 ± 0.105

0

Cathepsin A

0.456 ± 0.14

1.056 ± 0.320

0.697 ± 0.112

0.925 ± 0.325

Cathepsin B

0.462 ± 0.146

0.651 ± 0.151

0.262 ± 0.013b

0.768 ± 0.252

Cathepsin C

0.365 ± 0.231

0.35 ± 0.156

0.358 ± 0.178

0.325 ± 0.163

Cathepsin D

1.112 ± 0.352

1.125 ± 0.165

0.421 ± 0.154b

1.032 ± 0.257

Cathepsin E

0

0

0.103 ± 0.005c

0

Cathepsin L

0

0

0

0

Cathepsin S

0.728 ± 0.215

0.556 ± 0.124

0.592 ± 0.165

0.517 ± 0.201

Cathepsin V

0.19 ± 0.06

0.101 ± 0.004

0.878 ± 0.169a

0.05 ± 0.0

Cathepsin X/Z/P

0.628 ± 0.132

0.774 ± 0.268

0.312 ± 0.145b

0.575 ± 0.208

Kallikrein 3/PSA

0

0

0

0

Kallikrein 5

0.175 ± 0.112

0.272 ± 0.153

1.085 ± 0.312a

0.348 ± 0.114

Kallikrein 6

0.4 ± 0.105

0.472 ± 0.162

0.105 ± 0.05b

0.565 ± 0.151

Kallikrein 7

0

0

0.208 ± 0.101a

0.105 ± 0.04

Kallikrein 10

0.515 ± 0.231

0.547 ± 0.198

1.098 ± 0.305a

0.638 ± 0.246

Kallikrein 11

1.065 ± 0.289

0.985 ± 0.306

0.985 ± 0.268

0.745 ± 0.197

Kallikrein 13

0.5 ± 0.106

0.486 ± 0.113

0.266 ± 0.098b

0.698 ± 0.215

DPPIV/CD26

1.201 ± 0.316

0.857 ± 0.215

1.123 ± 0.298

1.157 ± 0.302

Neprilysin/CD10

0

0

0.394 ± 0.115

0.251 ± 0.108

Proprotein convertase 9

0.165 ± 0.05

0.201 ± 0.08

0

0.058 ± 0

Proteinase 3

0.415 ± 0.213

0.167 ± 0.09

0

0.383 ± 0.109

uPA/Urokinase

0

0

0.976 ± 0.296d

0.258 ± 0.107

Presenilin

0

 

0

0

  1. ADAM a disintegrin and metalloprotease, ADAMTS a disintegrin and metalloproteinase with thrombospondin motifs, MMP matrix metalloproteinases, uPA urokinase-type plasminogen activator
  2. a,bP < 0.05 compared with healthy controls or patients with CPD or OBM
  3. cOnly detected in OSCC saliva
  4. dP < 0.05 compared with CPD