Fig. 3 | International Journal of Oral Science

Fig. 3

From: The role of mechanotransduction versus hypoxia during simulated orthodontic compressive strain—an in vitro study of human periodontal ligament fibroblasts

Fig. 3

Effects of mechanotransduction vs. oxygen supply on hPDL fibroblast expression patterns and HIF-1α stabilization. a COX-2 mRNA, b PGE2 protein, c VEGF mRNA and d VEGF protein expression in the presence of pressure under normoxic (Lumox®) and hypoxic (polystyrene) conditions (N = 3, n = 9). e Representative immunoblot of HIF-1α protein expression. f Densitometric immunoblot analysis of HIF-1α protein expression (N = 4). Bars indicate mean values ± standard deviation. *P ≤ 0.05, **P ≤ 0.01, ***P ≤ 0.001. AU = arbitrary units

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