Fig. 3
From: Novel MSX1 variants identified in families with nonsyndromic oligodontia
Secondary and tertiary structure analysis of mutated MSX1 protein. a The predicted secondary structure of the wild-type MSX1 protein. b–f The predicted secondary structure of five mutated MSX1 proteins. Sites of variants are indicated by green squares. The structural changes in these mutated proteins compared to the wild-type MSX1 are indicated by orange squares. α-Helices are represented as pink squares, while coils are represented as grey squares. g The predicted three-dimensional models of HD in MSX1. h–k The three-dimensional structural changes of two missense variants. The wild-type (h, j) and mutated residues (i, k) are shown in black and red, respectively
