Fig. 2
From: Advances in biomineralization-inspired materials for hard tissue repair
Schematics, characterizations, and in vivo effects of intrafibrillarly mineralized collagen scaffolds. Structural schematics of (a1) native bone, (b1) HIMC, (c1) NIMC, and (d1) EMC, respectively. TEM images of (a2) native bone, (b2) HIMC, (c2) NIMC, and (d2) EMC, respectively. The HIMC shows bone-like periodical nanoarchitectures, whereas the NIMC shows no periodicity. In the EMC, HAP clusters deposit randomly outside collagen fibrils. e Micro-CT images and bone volume of different scaffolds at 12 weeks post-transplantation in rat mandibles. The HIMC shows similar bone repairing effects with the DCBM. f H&E and Masson stainings, and semiquantitative analysis of regenerated bones in rat mandibles. The HIMC and the DCBM groups show abundant neo-bone formation and regeneration of osteoblasts and bone marrow, which are more than those of the NIMC group. Reproduced with permission from ref. 78, 2019 Wiley-VCH
