Fig. 6

Schematic and in vivo experiments of PTL/C-AMG for enamel demineralization. a Schematic showing the similarity between amelogenin and PTL/C-AMG matrix in regulating the transition of ACP into HAP on enamel. b Schematic and photographs showing the process of fixing demineralized enamel slices in rat’s oral cavity. SEM images of c the untreated demineralized enamel, d demineralized enamel treated with fluoride, and e PTL/C-AMG film-treated demineralized enamel, after 2 weeks of remineralization in oral cavity. (c2), (d2), and (e2) are the corresponding high-magnification images of (c1), (d1), and (e1), respectively. The untreated group shows only incompact and irregular minerals. The fluoride group exhibits hollow cracks and irregular crystals. The PTL/C-AMG film group shows a “fish-scale” morphology that is similar to native enamel, and the newly formed crystals are highly oriented. Reproduced with permission from ref. ²³⁷, 2020 Wiley-VCH