Table 2 Top 10 KEGG enriched pathways for upregulated and downregulated genes in ICF-treated mouse iPSCs
Items | ID | Name | Number of Genes | FDR |
|---|---|---|---|---|
Upregulated pathway | mmu04115 | p53 signaling pathway-Mus musculus (mouse) | 22 | 2.95e-12 |
mmu05206 | MicroRNAs in cancer-Mus musculus (mouse) | 19 | 6.04e-04 | |
mmu03460 | Fanconi anemia pathway-Mus musculus (mouse) | 8 | 9.7e-02 | |
mmu05218 | Melanoma-Mus musculus (mouse) | 9 | 1.69e-01 | |
mmu01524 | Platinum drug resistance-Mus musculus (mouse) | 9 | 2.3e-01 | |
mmu04110 | Cell cycle-Mus musculus (mouse) | 12 | 2.3e-01 | |
mmu03440 | Homologous recombination-Mus musculus (mouse) | 6 | 2.54e-10 | |
mmu04068 | FoxO signaling pathway-Mus musculus (mouse) | 12 | 3.18e-01 | |
mmu05215 | Prostate cancer-Mus musculus (mouse) | 9 | 3.34e-01 | |
mmu00514 | Other types of O-glycan biosynthesis-Mus musculus (mouse) | 4 | 3.34e-01 | |
Downregulated pathway | mmu01230 | Biosynthesis of amino acids -Mus musculus (mouse) | 25 | 5.48e-11 |
mmu01200 | Carbon metabolism-Mus musculus (mouse) | 30 | 6.42e-11 | |
mmu01100 | Metabolic pathways-Mus musculus (mouse) | 130 | 6.42e-11 | |
mmu00010 | Glycolysis/gluconeogenesis-Mus musculus (mouse) | 19 | 9.15e-08 | |
mmu00100 | Steroid biosynthesis-Mus musculus (mouse) | 10 | 8.04e-07 | |
mmu00030 | Pentose phosphate pathway-Mus musculus (mouse) | 11 | 2.74e-05 | |
mmu00500 | Starch and sucrose metabolism-Mus musculus (mouse) | 11 | 3.36e-05 | |
mmu04066 | HIF-1 signaling pathway-Mus musculus (mouse) | 20 | 5.81e-05 | |
mmu03010 | Ribosome-Mus musculus (mouse) | 22 | 2.56e-04 | |
mmu00520 | Amino sugar and nucleotide sugar metabolism -Mus musculus (mouse) | 12 | 2.81e-04 |
