Table 1 In vivo therapeutic effects of DSC-EVs in oral diseases
Donor cells | Animal models | Therapeutic effects | Potential molecular mechanism | References |
|---|---|---|---|---|
DPSCs | Tooth root slice model in nude mice | Pulp regeneration | Promoting odontogenic differentiation of DPSCs via triggering P38 phosphorylation | |
Dental pulpotomy model in rats | Pulp regeneration | Inducing macrophage M2 polarization by delivering miR-125a-3p | ||
Periodontitis model in mice | Periodontal regeneration | Promoting macrophage M2 polarization via transferring miR-1246 | ||
Pulpotomy model in rats | Dentine regeneration | Not mentioned | ||
Pulpless root canal model in rats | Pulp regeneration | Not mentioned | ||
Dental pulp injury model in miniature pigs | Dentin regeneration | Not mentioned | ||
SHED | Tooth root slice model in nude mice | Pulp regeneration | Enhancing angiogenesis by transferring miR-26a that activated TGF-β/SMAD2/3 | |
Periodontitis model in mice | Periodontal regeneration | Not mentioned | ||
SCAP | Tooth root slice model in nude mice | Dentine regeneration | Not mentioned | |
GMSCs | Periodontitis model in mice | Periodontal regeneration | Delivering miR-1260b to inhibit the osteoclastogenic activity of periodontal ligament cells by targeting the Wnt5a-mediated RANKL pathway |
