Fig. 7

The schematic diagram showing the mediation axis from mechanical sensing, extracellular laminin β1 forming, focal adhesion protein FAK changing to cytoskeleton re-organization. Mechanical signals enter the chondrocytes to change the focal adhesion proteins, and then initiate the activation of signaling network, and finally regulate a variety of biological behaviors of the chondrocytes. The gray networks in the biomechanical regulation are involved but not presented in the current study; The red axis indicates the mediation process in the current study.