Fig. 4 | International Journal of Oral Science

Fig. 4

From: Kindlin-2 loss in condylar chondrocytes causes spontaneous osteoarthritic lesions in the temporomandibular joint in mice

Fig. 4

Kindlin-2 loss causes condylar chondrocyte hypertrophy and ECM degradation in condylar cartilage. a IF staining for expression of Aggrecan, Col2a1, Prg4, Col10a1, Runx2, and Mmp13 in control or cKO TMJs at 12 weeks post TM treatments. Red dashed boxes indicate the higher-magnification images in right panels. Scale bar: 50 μm. b–g Quantitative data of Aggrecan- (b), Col2a1- (c), Prg4- (d), Col10a1- (e), Runx2 (f), and Mmp13-expressing cells (g) in mandibular condylar cartilages of the two groups. Results are expressed as mean ± standard deviation (s.d.). n = 8 mice per group. ***P < 0.001

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