Fig. 6 | International Journal of Oral Science

Fig. 6

From: Histone demethylase JMJD3 downregulation protects against aberrant force-induced osteoarthritis through epigenetic control of NR4A1

Fig. 6

Akt signaling participates in aberrant force-mediated OA pathogenesis. a Akt signaling was activated in Ad-NR4A1-infected chondrocytes. b Treatment with Akt pathway inhibitor LY294002 effectively inhibited chondrocyte apoptosis induced by NR4A1. c Akt pathway inhibition partially rescued NR4A1-induced chondrocyte injury. d Representative markers for OA evaluation were investigated by western blot assay. e Aberrant mechanical force induced Akt signaling pathway activation. f Pretreatment with LY294002 prevented SNP-induced apoptosis activities in primary chondrocytes. g Akt pathway inhibition by LY294002 partially attenuated FSS-induced chondrocyte injury. h Representative markers for evaluating cartilage pathogenesis were detected. *P < 0.05; **P < 0.01; ***P < 0.001

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