Fig. 2
Effect of DMP1 expression on XLH DPSCs. A post hoc pairwise comparison was conducted between the samples. First, significantly differentially expressed genes (DEGs)(FDR < 0.01) between Ctrl and XLH samples were identified. This list of genes was further restricted to those genes that were differentially expressed between XLHDMP1 and XLH samples. A total of 778 DEGs are plotted (red and blue dots). The dotted lines represent Log2(FC) = −1 and 1 threshold (twofold decrease or increase, respectively). In blue, 336 genes are highlighted which exhibited a reversal in expression pattern with DMP1 expression (e.g., in the upper left quadrant are genes significantly downregulated in XLH vs. Ctrl cells, that were found to be upregulated in XLHDMP1 vs. XLH cells)
