Fig. 1 | International Journal of Oral Science

Fig. 1

From: RGS12 represses oral squamous cell carcinoma by driving M1 polarization of tumor-associated macrophages via controlling ciliary MYCBP2/KIF2A signaling

Fig. 1

RGS12 is a biomarker of oral squamous cell carcinoma. a Hierarchical clustering heat map of DEGs by human normal tissues and OSCC tissues. b KEGG pathway enrichment analysis of a. c Venn diagram of DEGs. Genes in overlapping sets show the differential expression in cancer signaling and immune response. d The 9 overlapping genes from c were performed by the prognostic markers analyses through the Human Atlas database. e Representative images of the immunohistochemical (IHC) staining for RGS12 in the human normal and OSCC tongue tissues. Scale bar, 100 μm. The right panel indicates the quantitative date of relative intensity in e. n = 3, **P < 0.01. f Survival curves of the HNSCC patients with high and low levels of macrophages and RGS12 from the Tumor Immune Estimation Resource (TIMER) platform. Statistical analysis among HNSCC subtypes was performed and compared using the log-rank test and P < 0.05 was considered to be significant

Back to article page