Fig. 4 | International Journal of Oral Science

Fig. 4

From: RGS12 represses oral squamous cell carcinoma by driving M1 polarization of tumor-associated macrophages via controlling ciliary MYCBP2/KIF2A signaling

Fig. 4

RGS12 in TAMs drives the polarization of M1 macrophages with increased cilia number and length compared with M2 macrophages. a, b Primary cilia in TAMs transfected with vector control or RGS12 overexpression (OE) vector (48 h) conditions (green, Ac-tubulin for cilia; blue, DAPI for nuclei) a. Scale bar, 10 μm. b The ciliated cell number and cilia length were calculated from the images in a. **P < 0.01, n = 5. c, d Primary cilia in TAMs from the WT control and RGS12 cKO mice c. Scale bar, 10 μm. d The ciliated cell number and cilia length were calculated from the images in c. ***P < 0.01, n = 5. e Pearson’s correlation analysis indicating RGS12 expression and M1/M2 macrophage markers in TAMs. Pearson’s correlation coefficient (r) and P-values are shown for each analysis (n = 5). f Correlation between cilia number/length and M1/M2 markers in TAMs. Pearson’s correlation (r) values and P-values are indicated within each graph (n = 5)

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