Fig. 9 | International Journal of Oral Science

Fig. 9

From: RGS12 represses oral squamous cell carcinoma by driving M1 polarization of tumor-associated macrophages via controlling ciliary MYCBP2/KIF2A signaling

Fig. 9

RGS12 promotes M1 macrophage polarization and ciliogenesis through MYCBP2. a TAMs from oral cancer tissues of WT mice were treated with pCMV (Ctrl) or pCMV-RGS12 (RGS12 OE) or pCMV-RGS12 + shMYCBP2 (RGS12 OE + shMYCBP2). Primary cilia were stained by immunofluorescent assay (Scale bar, 10 μm). b The ciliated cell numbers and cilia lengths of TAMs in (a) were analyzed by ImageJ software (NIH, US). Data are expressed as mean ± SEM (n = 5, **P < 0.01, ***P < 0.001). c, d TAMs were treated as described in a. The M1 macrophage (CD86) and M2 macrophage (CD163) were detected by immunofluorescence staining. Scale bar, 10 μm. **P < 0.01, ***P < 0.001, n = 5

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