Fig. 5 | International Journal of Oral Science

Fig. 5

From: Down-regulation of DNA key protein-FEN1 inhibits OSCC growth by affecting immunosuppressive phenotypes via IFN-γ/JAK/STAT-1

Fig. 5

The correlation between the immune-related cell surface molecules and the malignancy in OSCC. a1–d1 PD-L1 staining on normal tissue, OLK and OSCC tissue (n = 6). a2–d2 HLA-DR staining on normal tissue, OLK and OSCC tissue (n = 6). Scale bar: 100 μm. a3–d3 Representative image of DAPI staining in OLK and OSCC. a4–d4 Representative image of PD-L1 staining in OLK and OSCC. a5–d5 Representative image of HLA-DR staining in OLK and OSCC. Channels were separately presented for a clearer view. a6–d6 Co-immunostaining of HLA-DR and PD-L1 in OLK and OSCC. Scale bar: 200 μm. e, f Quantification of PD-L1 and HLA-DR expression level in normal, OLK and OSCC tissue. n = 6; error bars, mean ± SD, ****P < 0.000 1; t test or two-way ANOVA

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