Fig. 6 | International Journal of Oral Science

Fig. 6

From: Oral pathogen aggravates atherosclerosis by inducing smooth muscle cell apoptosis and repressing macrophage efferocytosis

Fig. 6

Fabrication of MM/SMNPs nanoparticles and its treatment for P. gingivalis-infected periodontitis and atherosclerosis. a Schematic illustration of SMNPs fabrication coated by P. gingivalis-pretreated macrophage membranes and delivery strategy in P. gingivalis-infected periodontitis (PD) and atherosclerosis (AS). b Schematic diagram of injection sites and frequency into ApoE−/− mice. c Plaque area in an aortic tree and d in the aortic root was examined by Oil Red O staining. n = 6. Scale bars: 200 μm. e Immunostaining staining and quantitation of apoptotic SMCs and CD86+ macrophages in serial plaque sections from control, SMNPs, and MM/SMNPs injected ApoE−/− mice. n = 6. Scale bars: 50 μm. Results are presented as the mean ± S.D. by one-way ANOVA followed by Tukey multiple comparisons tests. *P < 0.05; #P > 0.05

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