Fig. 1

Effect of DC depletion on the osteoinduction ability of BCP. a Schematic diagram of a transgenic mouse model. b, c H&E and Masson’s staining showed the formation of new bone (NB), indicated by the red dotted line. d IHC of COL1A1 showed expression of the osteogenesis indicator. Some representative positive cells are indicated with red arrows. e Comparison of quantitative COL1A1 expression (n = 4, P = 0.000 14)