Fig. 1 | International Journal of Oral Science

Fig. 1

From: Atp6i deficient mouse model uncovers transforming growth factor-β1 /Smad2/3 as a key signaling pathway regulating odontoblast differentiation and tooth root formation

Fig. 1The alternative text for this image may have been generated using AI.

Atp6i−/− mice exhibited arrested root formation, osteopetrosis phenotype due to impaired OC activity and increases the number of TRAP-positive osteoclasts in alveolar and femoral bone at 2 weeks. a TRAP and anti-CtsK IHC staining of representative mandibles in WT and Atp6i−/− mice groups. The middle and right panels are the black dotted boxed area from the left panels. b, c Quantification data of TRAP and anti-CtsK IHC staining of WT and Atp6i−/− mice groups. d TRAP and anti-CtsK IHC staining of representative femur in WT and Atp6i−/− mice groups. The middle and the right panels are the black dotted boxed area from the left panels. e, f Quantification data of TRAP and anti-CtsK IHC staining of WT and Atp6i−/− mice groups. n = 7 in each group; *** P < 0.001

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