Fig. 2 | International Journal of Oral Science

Fig. 2

From: Atp6i deficient mouse model uncovers transforming growth factor-β1 /Smad2/3 as a key signaling pathway regulating odontoblast differentiation and tooth root formation

Fig. 2The alternative text for this image may have been generated using AI.

Atp6i knockout mice exhibit disrupted tooth root formation with truncated HERS progression. a Representative radiograph and micro-CT images show defective molar root formation and eruption in 3-week-old Atp6i−/− mice compared to WT mice. b Representative photographic images show no tooth eruption (dotted box) and root development (first mandibular molar) in 3-week-old Atp6i−/− mice compared to WT mice. c Representative H&E staining images of first mandibular molars showing normal tooth development in 3-week-old WT mice and impaired root formation in Atp6i−/− mice of the same age. d–f Representative images of H&E staining of sagittal tooth sections from WT and Atp6i−/− mice of 4 days (d), 7 days (e) and 14 days (f) PN. HERS is delineated by the dotted lines and arrow. n = 7 in each group

Back to article page