Fig. 3 | International Journal of Oral Science

Fig. 3

From: Atp6i deficient mouse model uncovers transforming growth factor-β1 /Smad2/3 as a key signaling pathway regulating odontoblast differentiation and tooth root formation

Fig. 3The alternative text for this image may have been generated using AI.

Atp6i deficiency abolishes odontogenic cell proliferation and odontoblast differentiation during tooth root development. a–c IF staining of DSP, NFIC, and OSX in mandibular first molars from 4 days PN WT and Atp6i−/− mice. OD, Odontoblast (d, e) IHC staining of PCNA and nestin in WT and Atp6i−/− mice at 4 days PN. f Quantification of PCNA- and nestin-positive cell ratios in WT and Atp6i−/− mice groups. g qPCR analysis of the expression of odontoblast differentiation markers in alveolar bone-root samples from 4 and 14 day PN WT and Atp6i−/− mice. Hprt was used as an endogenous control. n = 7 in each group; *P < 0.05; **P < 0.01; ***P < 0.001

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