Fig. 4 | International Journal of Oral Science

Fig. 4

From: Atp6i deficient mouse model uncovers transforming growth factor-β1 /Smad2/3 as a key signaling pathway regulating odontoblast differentiation and tooth root formation

Fig. 4The alternative text for this image may have been generated using AI.

Smad2/3 activation in Atp6i Knockout mice is significantly suppressed. a IHC staining of p-Smad2/3 in odontoblasts of 4 day PN WT and Atp6i−/− mice. b Quantification data of p-Smad2/3 positive odontoblasts in WT and Atp6i−/− mice in (a). c IHC staining of Smad4 in odontoblasts in 4 days PN WT and Atp6i−/− mice. d Quantification data of Smad4 positive odontoblasts in WT and Atp6i−/− mice groups in (c). e Normal serum served as negative control. Dotted lines in (a, c) indicate the odontoblast cell layer. n = 7 in each group; **P < 0.01; ***P < 0.001

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