Fig. 1 | International Journal of Oral Science

Fig. 1

From: Divergent chondro/osteogenic transduction laws of fibrocartilage stem cell drive temporomandibular joint osteoarthritis in growing mice

Fig. 1

TMJ ADD in growing mice led to mandibular growth retardation. a Schematic diagram of ADD-induced TMJOA mouse model generation and timing of animal sacrifice after ADD surgery. b Representative images of morphological changes of ADD condyle compared to the control condyle. c To analyze the condyle growth of ADD mice, mandibles were dissected and scanned by microCT and were reconstructed at 2/4/8 weeks post-surgery. d–f The ramus height (RH), condylar width (CW), and condylar length (CL) of ADD mice were analyzed. n = 5–7. ****P < 0.0001. The horizontal line and error bar indicates mean ± SD. g H&E staining of TMJ condylar cartilage 1/2/4/8 weeks after ADD surgery. FZ fibrocartilage zone, PZ proliferative zone, AC articular cartilage. h–j The semi-quantification of cell number in articular cartilage, the thickness of articular cartilage, and the ratio of (FZ + PZ) thickness/articular cartilage thickness. N = 6–9. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.000 1

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