Fig. 1 | International Journal of Oral Science

Fig. 1

From: Knockdown of PGC1α suppresses dysplastic oral keratinocytes proliferation through reprogramming energy metabolism

Fig. 1

PGC1α knockdown suppressed DOKs proliferation. a, b The expression of PGC1α was detected by RT-PCR (a) or western blot (b) in DOKs after being infected with PGC1α knockdown or control lentivirus. c CCK-8 assays detected growth curves of DOKs. d A colony-formation assay was performed to measure the number of colonies in the control and shPGC1α DOK cells, the scale bar indicates 200 μm. e Xenograft tumors were shown. f Weight of xenograft tumors. g Growth curves of xenograft tumors in control and shPGC1α DOKs were shown during the 4 weeks. h CCK-8 assay in DOKs treated with SR18292 (0–75 μmol·L−1) for 24, 48, or 72 h. i Western blot analyses of PGC1α expression in DOKs treated with SR18292 (0–75 μmol·L−1) for 48 h. j SR18292 inhibits the growth of the DOK xenograft tumors model. k Weights of xenograft tumors mice of each group. l Growth curves of xenograft tumors from DOK tumor-bearing mice injected with 5% DMSO or SR18292 daily for 15 days. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.000 1

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