Fig. 5 | International Journal of Oral Science

Fig. 5

From: Knockdown of PGC1α suppresses dysplastic oral keratinocytes proliferation through reprogramming energy metabolism

Fig. 5

PGC1α knockdown enhances the glycolytic in DOKs by upregulating LDHA. a Glycolysis/gluconeogenesis was analyzed using GSEA assays in the shPGC1α or control group. b Heatmap of the analyzed geneset of glycolysis/gluconeogenesis gene sets in the shPGC1α or control group. c RT-PCR analysis of the cell cycle gene in (b). d The association networks between PGC1α and LDHA gene were got form the Serach Tool for the Retrieval of Interacting Genes (STRING) database. e Western blot analysis was performed for the protein level of PGC1α and LDHA in DOKs in the shPGC1α or control group. **P < 0.01, ***P < 0.001, ****P < 0.000 1

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