Fig. 3
From: MLL1 inhibits the neurogenic potential of SCAPs by interacting with WDR5 and repressing HES1
Histopathological changes in the SCI model after SCAP transplantation. a HE staining results revealed that the SCAP/MLL1sh group had more vacuolar cells and fewer cavities and scars than the SCI and SCAP/Scramsh groups. Scale bar, 100 μm and 500 μm. b, c The immunohistochemical results indicated that the SCAP/MLL1sh group exhibited significantly higher levels of Nestin expression compared to the SCAP/Scramsh group. Scale bar, 100 μm. d, e The immunofluorescence results indicated that h-mitochondria-positive cells were in the injury area in SCAP/Scramsh and SCAP/MLL1sh groups at 5 weeks after transplantation. Scale bar, 50 μm. f, g Immunofluorescence staining was used to observe the NEFM expression. Scale bar, 50 μm. Statistical significance was determined using one-way ANOVA, or the Kruskal–Wallis test. All error bars represent SD. (n = 6). **P ≤ 0.01
