Fig. 8
From: MLL1 inhibits the neurogenic potential of SCAPs by interacting with WDR5 and repressing HES1
MLL1 directly regulated the transcription of HES1 and IL-6 by binding with WDR5. The ChIP assay results showed that WDR5 knock-down reduced the binding of MLL1 to the HES1 (a) and IL-6 promoters (b), except for the NR4A2 promoter region (c); The ChIP assay results showed that WDR5 over-expression increased the binding of MLL1 to the HES1 (d) and IL-6 promoters (e), except for the NR4A2 promoter region (f). Statistical significance was determined using Student’s t test. All error bars represent SD. (n = 3). *P ≤ 0.05. **P ≤ 0.01
