Fig. 4

Transcriptomic change of DEOs cultured in Jagged1-depleted, FGF10-supplemented medium. a A dot plot of GO overrepresentation results for upregulated (Up) and downregulated (Down) DEGs in DEOs grown in +NF compared with DEOs grown in +NJ. The color and size of the dots indicate the P-value and gene ratio of each representative GO term. Volcano plots of DEGs of DEOs grown in +NF compared with DEOs grown in +NJ. Total (b and c) or indicated GO term-related (d, e) genes are displayed as red (|fold change| > 2 and P-value < 0.001), blue (|fold change| < 2 or P-value > 0.001), and gray (not related to the indicated GO term) dots. Vertical dashed lines indicate −2-fold and +2-fold changes. A horizontal dashed line indicates a P-value of 0.001