Fig. 1 | International Journal of Oral Science

Fig. 1

From: Oral administration of Bifidobacterium breve improves anti-angiogenic drugs-derived oral mucosal wound healing impairment via upregulation of interleukin-10

Fig. 1

Anti-angiogenic drug sunitinib causes oral mucosal wound healing impairment in mice. a Schematic diagram of the experimental protocol. b Macroscopic observation shows mucosal wound healing of the palate in mice after different treatments (scale bar: 1 mm). c Quantitative analysis of the relative wound area 14 days post-surgery. d Micro-CT three-dimensional reconstruction displays bone of palate in mice. Scale bar: 1 mm. e, f Statistical diagram shows the bone volume (mm3) and bone mineral density (Hounsfield unit) of palate bone under the mucosal defect. Each dot represents one mouse in two independent experiments of six mice per group. The data were analyzed with one-way ANOVA and presented as mean ± SD (*P < 0.05; ***P < 0.001; ****P < 0.000 1; ns not significant)

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