Fig. 4 | International Journal of Oral Science

Fig. 4

From: Oral administration of Bifidobacterium breve improves anti-angiogenic drugs-derived oral mucosal wound healing impairment via upregulation of interleukin-10

Fig. 4

Oral administration of B. breve meliorates wound healing impairment caused by sunitinib. a Schematic diagram of the experimental protocol. b Macroscopic observation shows that mucosal wound healing of the palate in mice after different treatments (Scale bar: 1 mm). c Quantitative analysis of the relative wound area 14 days post different treatments. Each dot represents one mouse in two independent experiments of five mice per group. d–g The expression level of IL-1β, IL-6, IFN-γ, and IL-10 in the mucosa detected by ELISA. The data were analyzed with one-way ANOVA and presented as mean ± SD (*P < 0.05; **P < 0.01; ***P < 0.001; ****P < 0.000 1; ns not significant)

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