Fig. 5
From: Magnesium promotes vascularization and osseointegration in diabetic states
Mg2+ promotes vascularization and osseointegration in diabetic mice. a Representative images of μCT reconstruction of the newly formed bone (blue) with implants and without implants (gray) 7 days post-surgery. Scale bar = 100 μm. b Quantitative analyses of bone-implant contact rate (BIC) and bone volume/tissue volume (BV/TV) (n = 6). c Representative images of the histological sections, red for bone. Scale bar = 50 μm. d Quantitative analyses of BIC and BV/TV in histological sections (n = 6). e Tissue clearing–based three-dimensional images around implants showed angiogenesis and osteogenesis on day 7 after surgery, with tdTomato signal displaying blood vessels (red), second harmonic generation (SHG) signal displaying bone (green) and implant (gray). Scale bar = 100 μm. f Quantitative analyses of vessel volume and SHG around implants (n = 6)
