Fig. 7 | International Journal of Oral Science

Fig. 7

From: Cuproptosis-related lncRNA JPX regulates malignant cell behavior and epithelial-immune interaction in head and neck squamous cell carcinoma via miR-193b-3p/PLAU axis

Fig. 7

JPX/miR-193b-3p/PLAU signaling axis entwined with malignant cell behaviors and drug resistance in HNSCC. a, b The spatial distribution of epithelial cells and PLAU. c The expression levels of PLAU with T-stage. Kruskal−Wallis test: *P < 0.05, **P < 0.01, and ***P < 0.001. d Schematic diagram of the mechanism by which the JPX/miR-193b-3p/PLAU axis mediates HNSCC. e Immunofluorescence images for the localization and the expression of Ki-67 and PLAU in HNSCC clinical samples. n = 7 per group. 40×, scale bar = 50 μm. f Immunohistochemical images for the localization and the expression of PLAU in HNSCC clinical samples. n = 7 per group. Quantitative analysis of positive areas is also shown. 10×, scale bar = 200 μm. 40×, scale bar = 50 μm. Wilcoxon signed-rank test: *P < 0.05, **P < 0.01, and ***P < 0.001

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