Fig. 4

Transcriptomic data from BMSCs were utilized to validate the role of Vtn+ fibroblasts in soft tissue regeneration, as evidenced by the scRNA-seq analysis results. a Schematic representation of the transcriptome experimental design. The diagram generated in part with BioRender.com. b The GO enrichment analysis of upregulated genes between the EMD-treated and control groups. c Heatmap of cell type proportions estimated from mRNA-seq data after deconvolution analysis. d Box plots illustrated the proportions of Vtn+ fibroblasts and proliferative cells in EMD-treated and control groups. e CCK8 results of EMD treated cells. f, g GO enrichment analysis for Vtn+ fibroblasts and MSCs based on scRNA-seq data.The bar plot displays enriched GO terms