Fig. 8

Comparative analysis of cellular interactions and signaling patterns between EMD and control conditions. a Circular network plots depicting the interaction weights/strengths among various cell types under EMD and control conditions. Each node represents a cell type, with the size of the node corresponding to the number of interactions. The thickness and color of the edges indicate the strength and nature of the interactions, respectively. The plot on the left illustrates interactions under EMD conditions, while the plot on the right shows interactions under control conditions. b, c Dot plot visualizing the communication probabilities of selected signaling pathways under EMD conditions. The x-axis lists the interacting cell types, while the y-axis lists the specific signaling pathways. The size of the dots represents the P-value significance of the interaction, and the color intensity indicates the communication probability. d Heatmaps depicting the outgoing (left) and incoming (right) signaling patterns of different cell types. The x-axis lists the source cell types, while the y-axis lists the target cell types. The color intensity reflects the relative strength of signaling from source to target cells. Outgoing signaling patterns show how different cell types under EMD and control conditions send signals, while incoming patterns illustrate how they receive signals