Fig. 2 | International Journal of Oral Science

Fig. 2

From: Role and mechanisms of histone methylation in osteogenic/odontogenic differentiation of dental mesenchymal stem cells

Fig. 2

KMTs and KDMs mediate histone methylation modifications. a The MLL1/2, MLL3/4 complex catalyzes mono- and dimethylation of H3K4, MLL1 is responsible for H3K4 trimethylation, while KDM5A facilitates the demethylation of H3K4me2 and H3K4me3. LSD1 is responsible for the demethylation of H3K4me1 and H3K4me2. b SETDB1 and G9a are involved in the mono/dimethylation of H3K9, while Suv39h1 is responsible for the di-/trimethylation of H3K9. The demethylation of H3K9 is mediated by the JHDM2/KDM3 family, the JHDM3(JMJD2)/KDM4 family, and PHF8/KDM7B; c EZH2 is the major lysine methyltransferase of H3K27, while KDM6A/B catalyzes the demethylation of H3K27me1/2/3

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