Fig. 5 | International Journal of Oral Science

Fig. 5

From: Role and mechanisms of histone methylation in osteogenic/odontogenic differentiation of dental mesenchymal stem cells

Fig. 5

Role of H3K27 histone methylation modification in osteo-/odontogenic differentiation of bone/dental-derived MSCs. a PRC2 protein complex. b EZH2 has been demonstrated to antagonize the function of KDM6A/B and to co-regulate the level of H3K27me3. c PRC2 core subunit EZH2 has been shown to catalyze H3K27 trimethylation and maintain gene silencing, thereby inhibiting the osteogenic differentiation of DMSCs. The specific demethylase KDM6A has been demonstrated to enhance the osteogenic differentiation potential of DMSCs by removing the H3K27me3 mark at the Runx2 and Ocn transcription start sites. KDM6B is required for osteogenic differentiation, with KDM6B binding to BMP2 and HOX genes and co-regulating downstream OSX, BGLAP, and SPP1 transcription

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